Endocrine Abstracts

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients suffering from metabolic syndrome hypertension, hyperinsulinemia and postprandial hyperglucagonemia are common features. It was the aim of the present study to evaluate the impact of glucagon on proANP and the possible mechanisms ...

Objectives: Gastrointestinal hormones are known to modulate satiety. The mechanisms underlying the impact of glucagon on satiety are so far unknown. However, it can be postulated that the glucagon-induced reduction in hunger feeling is mediated through changes in Cholecystokinin (CCK), which is known to play a role in meal termination. It was the aim of the present study to evaluate the impact of glucagon on CCK and the modulation of these effects in obesity.<p class="abst...

Objective: Adiposity, insulin resistance, and hyperandrogenism are features of the polycystic ovary syndrome (PCOS). Retinol-binding protein 4 (RBP4) secreted from adipose and liver tissue has been linked to insulin resistance. We here address the impact of RBP4 on insulin resistance in PCOS and its usability to identify women with metabolic syndrome or impaired glucose metabolism (IGT or diabetes).Design: RBP4 was determined in plasma of 115 PCOS...

Background: The mechanisms underlying the association between severe hypoglycaemia and increased cardiovascular mortality among patients with diabetes mellitus are not fully understood. Our aim was to evaluate changes in GH/IGF1 axis during insulin-induced hypoglycaemia, as a possible link.Methods: Twenty-five healthy subjects, 12 obese participants (OP; 6/ 6; 34.4±1.7 kg/m2), and 13 healthy lean participants (LP; 6/ 7; 21.7±0.6 kg/m...

Objectives: GH measurements during OGTT have profound effects on therapy and follow-up management of acromegaly. To minimize the discordance between immunoassays, it is recommended to calibrate them using 22 kDa-GH-preparation instead of the use of pituitary-derived calibrants. The aim of our study was to evaluate the between-method discrepancies in GH determinations by assays using different calibrants considering further confounders like age, gender, and BMI.<p class="ab...

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. As we showed recently, the glucagon-induced reduction in total ghrelin, that might be responsible for this effect, is exerted at hypothalamus–pituitary level. The aim of the present study was to further evaluate glucagon’s suppressive effect on both total and acylated-ghrelin in obesity with respect to its role in appetite control.Methods: Prospecti...

Context: The polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism and associated with obesity and impaired glucose metabolism. Despite the high prevalence of PCOS and the considerable clinical impact, the precise interplay between metabolism and hyperandrogenemia is not entirely clear. We therefore aimed to analyse the relation between circulating free fatty acids (FFAs) and androgen metabolism in vivo in women.Design and partic...